Research Autism/Diet/GI

Autism and Diet Study Guide

This is not intended as medical advice, it is for research purposes only. This is also a rough draft and will be expanded on in the future. This is not to promote any particular diet. It is intended to help parents and other interested parties be aware of research and information that is available on the subject of autism, diet and gi dysfunction.

-Current Research Specifically for Autism (updated 8/29/2012)
-Vitamins, Minerals and Other Nutrients (updated 4/7/2013)
-Special Diets, Picky Eating,  and Malnutrition Concerns(updated 11/20/2011)
-Food Allergy and Gut Dysfunction
-All in the Family (updated 8/19/2011)
-Why Gluten?
-Those Crazy Yeast Theories
-Other Links


Studies Implicate Gut Bacteria in Autism

Autism and the Human Gut Flora by Dr. Max Bingham published on the Environmental Illness Resouce

Autism test could make the condition 'preventable' By Richard Alleyne, Science Correspondent
Published: 6:00PM BST 03 Jun 2010 by the Telegraph

Autism: It's Not Just in the Head by Jill Neimark Discover Magazine April 2007

Autism: a rising problem Original Internist, Sept, 2003 by Nikhil V. Jathar, Vithal S. Jathar

Current Research

A Microbial Association with Autism

Low Relative Abundances of the Mucolytic Bacterium Akkermansia muciniphila and Bifidobacterium spp. in Feces of Children with Autism

Gut Microbiota and Pediatric Disease

Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances

Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes.

Gastrointestinal flora and gastrointestinal status in children with autism -- comparisons to neurotypical children and correlation with autism severity.

Intestinal Microflora of Autistic Children

Biomedical Treatments for Autistism Spectrum Disorders Scientific References and Abstracts. A site maintained to offer medical literature on the biomedical interventions in autism.

Alterations of the Intestinal Barrier in Patients With Autism Spectrum Disorders and in Their First-degree Relatives

Pyrosequencing study of fecal microflora of autistic and control children.

Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report in Journal of Pediatrics Published online January 4, 2010

Listen to Speech from Maine CDC Autism Conference 2009
Gastrointestinal and Nutritional Co-Morbidities in Autism by Timothy Biue, M.D. ( Pediatric Gastroenterologist, LADDERS Program, MassGeneral Hospital for Children Harvard Medical School)

Gastrointestinal Illness In Autism: An Interview with Tim Buie, M.D. by Kulani Mahikoa In Autism Advocate

Is There a Link Between Autism and the Gut? Interview with Timothy Buie, M.D.

Autism spectrum disorders and allergy: observation from a pediatric allergy/immunology clinic

Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder.

Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation

Gastrointestinal symptoms in a sample of children with pervasive developmental disorders.

The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders.

Effectiveness of the Gluten‐Free, Casein‐Free Dietary Treatment for Children Diagnosed with Autism Spectrum Disorder: Based on Parental Report

Autistic Disorder and GI Disease by Karoly Horvath M.D.,Ph.D. and Jay A. Perman M.D.

Gastointestinal Pathology in Autism: Description and Treatment Arthur Kriggsman, M.D.

Gut Microorganisms and Autism: the Latest Research This site is loaded with research!

The Autism Research Institute also has Advances In Research : Table Of Contentswhich has links to research abstracts on autism related health topics

Vitamins, Minerals and other Nutrients

Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutrition and Metabolism 6/2011

Infantile zinc deficiency: Association with autism spectrum disorders

Special Diets, Picky Eating, and Malnutrition Concerns

Pediatric Academic Societies Meeting - Lack of Food Variety Puts Kids with Autism at Risk for Poor Nutrition

Does nutritional intake differ between children with autism spectrum disorders and children with typical development?

Dietary intake and parents' perception of mealtime behaviors in preschool-age children with autism spectrum disorder and in typically developing children.

Reduced bone cortical thickness in boys with autism or autism spectrum disorder

Adherence to food-based dietary guidelines and evaluation of nutrient intake in 7-year-old children

Gluten and casein free diets in autism: a study of the effects on food choice and nutrition.

Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship to gastrointestinal symptoms and dietary intervention.

Food Allergy and Gut Dysfunction

Article: Autism Spectrum Disorders and Allergy: Possible Effects of Allergic & Nonallergic Disorders on Cognition & Behavioral Symptoms

Non-IgE mediated food allergy

Neuroimmune interaction and anorectal motility in children with food allergy-related chronic constipation.

Educational clinical case series for pediatric allergy and immunology: allergic proctocolitis, food protein-induced enterocolitis syndrome and allergic eosinophilic gastroenteritis with protein-losing gastroenteropathy as manifestations of non-IgE-mediated cow's milk allergy.

Allergic gastrointestinal motility disorders in infancy and early childhood.

Gastrointestinal manifestations of food allergies in pediatric patients.

The spectrum of gastrointestinal allergies to food.

Colonic lymphoid nodular hyperplasia in children: relationship to food hypersensitivity.

Association of eosinophilic gastrointestinal disorders with other atopic disorders.

The link between allergies and eosinophilic esophagitis: implications for management strategies.

Clinical presentation of feeding dysfunction in children with eosinophilic gastrointestinal disease.

Gastroesophageal reflux (GER) in children and adolescents with regard to food intolerance

Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial.

All in the Family

The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members.

Association of family history of autoimmune diseases and autism spectrum disorders.

Gastrointestinal symptoms in children with an autism spectrum disorder and language regression.

Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders.

Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism

Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions.

Familial association between type 1 diabetes and other autoimmune and related diseases.

Familial association of inflammatory bowel diseases with other autoimmune and related diseases.

Familial associations of rheumatoid arthritis with autoimmune diseases and related conditions.

Mannose-binding lectin and maladies of the bowel and liver.

Why Gluten?

[The predictive value of antigliadin antibodies (AGA) in the diagnosis of non-celiac gastrointestinal disease in children]

Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines.

Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms

Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives

Role of Intestinal Bacteria in Gliadin-Induced Changes in Intestinal Mucosa: Study in Germ-Free

Those Crazy Yeast Theories

Yeasts: neglected pathogens

Ecology of Candida albicans gut colonization: inhibition of Candida adhesion, colonization, and dissemination from the gastrointestinal tract by bacterial antagonism.

Antibodies against glucan, chitin, and Saccharomyces cerevisiae mannan as new biomarkers of Candida albicans infection that complement tests based on C. albicans mannan.

Cleavage of E-cadherin: a mechanism for disruption of the intestinal epithelial barrier by Candida albicans.

Aberrant responses to TLR agonists in pediatric IBD patients; the possible association with increased production of Th1/Th17 cytokines in response to candida, a luminal antigen.

Candida albicans is an immunogen for anti-Saccharomyces cerevisiae antibody markers of Crohn's disease

[Anti-glycan antibodies establish an unexpected link between C. albicans and Crohn disease]

Anti-Saccharomyces cerevisiae antibodies in coeliac disease.

Disappearance of anti-Saccharomyces cerevisiae antibodies in coeliac disease during a gluten-free diet

Anti-Saccharomyces cerevisiae antibodies are frequent in type 1 diabetes

Diagnostic Role and Clinical Association of ASCA and ANCA in Brazilian Patients with Inflammatory Bowel Disease.

Serological markers in inflammatory bowel disease: a review of their clinical utility.

Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability.

Anti-Saccharomyces cerevisiae antibodies--a novel serologic marker for Beh├žet's disease.

Effect of Candida albicans cell wall glucan as adjuvant for induction of autoimmune arthritis in mice.

Preventive strategy for Candida gut translocation during ischemia-reperfusion injury supervening on protein-calorie malnutrition.

Other Links

Roos Clues a blog by a mother of an almost recovered son. She discusses research and other topics on autism and autoimmunity

Behavioural Neurotherapy Clinic "ADHD, Adult ADHD, Learning Difficulties, Dyslexia, autism and IBS have underlying causes, which we are committed to investigating and treating. "

The Seat of the Soul; The Origins of the Autism Epidemic by ANDREW WAKEFIELD, MB, BS, FRCS, FRCPath Presented at Carnegie Mellon University, November 17, 2005 (By a controversial figure in autism, but well worth reading).

Stan Kurtz A parent-researcher-autism activist