If You Give a Lab Mouse a Cookie

Here's my grown up geeky version of If You Give a Mouse a Cookie by Laura Joffe Numeroff. I have bookmarked a few pieces of interesting research that involve mice. Some of these articles involve inducing a condition to test new drugs. For example, say you need to test a drug for epilepsy or colitis, instead of trying to locate thirty mice with the condition, you induce it. As someone who never paid attention in biology class, this was news to me...and what was used to induce was sometimes more interesting than what they induced for. Please note I'm not trying to make fun of the poor plight of lab mice, who give their lives for our benefit.

If You Give a Lab Mouse a Cookie

If you give a lab mouse a cookie and them give him a glass of water with chlorinated by-products to wash it down with, he develops autistic symptoms: Chlorination byproducts induce gender specific autistic-like behaviors in CD-1 mice, post on Questioning Answers,
And cancer: Assessment of the carcinogenic potential of chlorinated water: experimental studies of chlorine, chloramine, and trihalomethanes

If you give a lab mouse a cookie with MSG and partially hydrogenated vegetable shortening he develops fatty liver disease: Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease, and becomes forgetful: Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory

If you give a lab mouse a cookie with MSG he develops a smorgasbord of creepy health issues: Atorvastatin improves insulin sensitivity in mice with obesity induced by monosodium glutamate,
Long term effect of monosodium glutamate in liver of albino mice after neo-natal exposure,
Effects of bezafibrate in nonalcoholic steatohepatitis model mice with monosodium glutamate-induced metabolic syndrome, Chronic Administration of Monosodium Glutamate under Chronic Variable Stress Impaired Hypothalamic-Pituitary-Adrenal Axis Function in Rats,

If you give a lab mouse a cookie with MSG or Aspartame he becomes forgetful again: Glutamate and aspartate impair memory retention and damage hypothalamic neurons in adult mice

If you give a lab mouse a low-protein cookie and candida yeast, he develops colon permeability and evasive candida: Preventive strategy for Candida gut translocation during ischemia-reperfusion injury supervening on protein-calorie malnutrition.

If you give a Syrian hamster (not a mouse, but everyone is welcome here) a cookie with antibiotics and candida yeast, his protective gut flora is wiped out and candida is found in his organs: Ecology of Candida albicans gut colonization: inhibition of Candida adhesion, colonization, and dissemination from the gastrointestinal tract by bacterial antagonism.

If you give a pregnant lab mouse a cookie with antibiotics her offspring have affected immune systems: See post at Gutness Gracious Me

If you give a lab rabbit a cookie with LPS he develops colitis. (actually he's injected with it, not eating it)  Lipopolysaccharide-induced colitis in rabbits. What is LPS? It is short for lipopolysaccharide, which is a toxin put off by gram-negative bacteria in your gut. Too much is a bad thing, which can also give the rabbit, an yourself, a host of bad issues: depression, anti-social behavior, liver problems, kidney problems, gi problems, etc. There is a wonderful website covering this called Microbial Influence.

If you give a lab mouse a cookie with high fructose corn syrup and trans-fat, the same amount to correlate with an American fast food diet, he develops metabolic syndrome: Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent

If you give a lab mouse a cookie with azo dyes (such as red 40), he develops DNA damage in his colon: DNA Damage Induced by Red Food Dyes Orally Administered to Pregnant and Male Mice

What's in your cookie?

This post is linked to Sunday School, Monday Mania, Fightback Friday, and Real Food 101.